A Study of Bio-medical Image Registration Algorithms

Bio-medical Image Registration has greater impact on image analysis. Image Registration technique helps to align two images, which uses intensity of pixels as prime factor for registration. The images used for registration can be either mono-modal or multi-modal. The degradation of image is frequently observed during image acquisition itself, which affects registration considerably. The performance of algorithms should be independent of image degradations. The most commonly used techniques for similarity measures to perform image registration include Sum of Absolute Difference (SAD), Sum of Squared Differences (SSD), and Normalized Cross Correlation (NCC) methods. In this paper a comparative study is done to obtain better algorithm. A set of images were taken for the study and were modified by varying contrast and relative shift. The obtained results show that SAD method is best suited to perform registration of mono-modal images. Keywords— Image Registration, SAD, SSD, NCC